Avior Bio Inc.

Technology

Speedit™ Transmucosal Film Technology

  • Speedit is an oral thin film wherein drug nano-/microparticles resides on the surface of the film.
  • Speedit™ provides fast onset, enhanced permeation, reduced variability, and high bioavailability.
  • Speedit™ offers avoidance of first pass metabolism and significant reduction in glucuronide metabolites which are predominantly excreted by the kidney.
  • Speedit™ offers low manufacturing COGS.

Pipeline

Results

AV104 completely suppression of Substance P-induced pruritus in C57BL mice as captured as a function of time every 10 minutes in a model that mimics a rodent model first generated by Andoh et al. (figure on the right).

The results in Figure below show the pruritic pharmacodynamics captured by the number of scratches induced by Substance P and anti-pruritic effectiveness of AV104 when given prophylactically.

Andoh, T, et al. “Involvement of Leukotriene B4 in Substance P induced Itch Associated Response in Mice,” J. Investig. Dermatolog., 117 (6): 1621-1625 (2001)

AV104 films using the Speedit™ transmucosal technology demonstrate rapid absorption and high bioavailability of drug in a beagle dog model as compared to RLD