AV104 completely suppression of Substance P-induced pruritus in C57BL mice as captured as a function of time every 10 minutes in a model that mimics a rodent model first generated by Andoh et al. (figure on the right).
The results in Figure below show the pruritic pharmacodynamics captured by the number of scratches induced by Substance P and anti-pruritic effectiveness of AV104 when given prophylactically.
Andoh, T, et al. “Involvement of Leukotriene B4 in Substance P induced Itch Associated Response in Mice,” J. Investig. Dermatolog., 117 (6): 1621-1625 (2001)
AV104 films using the Speedit™ transmucosal technology demonstrate rapid absorption and high bioavailability of drug in a beagle dog model as compared to RLD