Avior Bio Inc.

Therapeutic Focus

Moderate to Severe Pruritus

Intermittent moderate-to-severe -pruritus (itch) is a common comorbid symptom of chronic liver diseases such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), alcoholic liver disease (ALD), fatty liver disease (FLD), hepatitis (B/C), and liver cirrhosis. It is estimated that over 2.5 million patients suffer from intractable, persistent pruritus in liver disease patients with no FDA approved therapies currently available. Pruritus in liver disease is a refractory symptom and it reduces the patients’ quality of life (QOL) causing insomnia, anxiety, depression, nocturnal scratching, excoriation, and bleeding.

The disease state is also common in atopic dermatitis (eczema) where 91% of the 15.6 million patients experience pruritus. However, despite new therapies to treat atopic dermatitis, approximately 31% do not find relief for their pruritus.

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Prevalence

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  1. Mollanazar NK, Koch SD, Yosipovitch G , Epidemiology of chronic pruritus: where have we been and where are we going? Curr. Dermatol Rep. 2015; 4(1):20–29
  2. Oeda, S, et al. Prevalence of pruritus in patients with chronic liver disease: A multicenter study, Hepatology Research, 2018; 48: E252–E262.